PATHOMORPHOLOGY OF FIBROSING PROCESSES IN THE LIVER AND LUNGS IN PATIENTS WITH NON-ALCOHOLIC STEATOHEPATITIS AND OBESITY AT COMORBIDITY WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Objective - to study the histochemical and histological features of liver lungtissues in patients with non-alcoholic steatohepatitis (NASH) obesity under conditionof a comorbid course chronic obstructive pulmonary disease (COPD).Material methods. The autopsy material 27 cases NASH, including 13 casesof NASH I degree (group 1), 14 withcomorbid COPD II-III stage 2) was used. groups comparison includedautopsy 12 isolated (Group 3), as wellas 11 practically healthy persons (PHP), their main causes death were polytraumaor traumatic brain injury or sudden coronary death. randomizedaccording age, sex, obesity. average age (59,3 ± 3,21)years.Results. volume connective tissue (CT) parenchyma 2nd groupwas 1,9 times higher than 1st group (p<0,05), specific collagenfibers 1,4 times, optical density collagen fibers by 1,2 (p<0,05). In 2ndgroup, maximum damage respiratory parts lungs (RPL) establishedin terms percentage filling RPL spaces desquamated cells (in 9.4 incomparison PHP, 1,3 compared indicator 3rd group); specificvolume growth blood vessels peribronchial CT Thephenomena venous thrombosis are most pronounced both CT(they exceed times) lungs(by 2,4 Patients had highest values among all (19,8 0,37 (p <0,05)).Conclusions. comorbidity contributedto activation components liverparenchyma indicators against background obesitywithout COPD, an increase times,p<0,05), (by p<0,05), ofcollagen coloring p<0,05).